{"id":60,"date":"2017-11-17T16:20:23","date_gmt":"2017-11-17T16:20:23","guid":{"rendered":"https:\/\/bussemakerlab.org\/site\/?page_id=60"},"modified":"2018-03-01T21:47:08","modified_gmt":"2018-03-01T21:47:08","slug":"collaborators","status":"publish","type":"page","link":"https:\/\/bussemakerlab.org\/site\/collaborators\/","title":{"rendered":"COLLABORATORS"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:0px;padding-bottom:100px;padding-left:0px;margin-bottom: 0px;margin-top: 0px;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height fusion-no-medium-visibility fusion-no-large-visibility\" style=\"margin-top:0px;margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\"><\/style><div class=\"fusion-title title fusion-title-1 fusion-title-center fusion-title-text fusion-title-size-one\" style=\"margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><div class=\"title-sep-container title-sep-container-left\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#c4c2c2;\"><\/div><\/div><span class=\"awb-title-spacer\"><\/span><h1 class=\"title-heading-center\" style=\"margin:0;\">Collaborators<\/h1><span class=\"awb-title-spacer\"><\/span><div class=\"title-sep-container title-sep-container-right\"><div class=\"title-sep sep-double sep-solid\" style=\"border-color:#c4c2c2;\"><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:40px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 20px 20px 20px 20px;\"><div class=\"fusion-menu-anchor\" id=\"Tuuli Lappalainen\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"width:25%;width:calc(25% - ( ( 2% ) * 0.25 ) );margin-right: 2%;margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"awb-image-frame awb-image-frame-1 imageframe-liftup\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-1\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"http:\/\/themannlab.org\" target=\"_blank\" aria-label=\"TuuliLab\" rel=\"noopener noreferrer\"><img decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/03\/TuuliLab-e1519939080412-300x300.png\" alt class=\"img-responsive wp-image-170\"\/><\/a><\/span><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_3_4 3_4 fusion-three-fourth fusion-column-last\" style=\"width:75%;width:calc(75% - ( ( 2% ) * 0.75 ) );margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><h3><a href=\"https:\/\/tllab.org\" target=\"_blank\" rel=\"noopener\">Tuuli Lappalainen<\/a><\/h3>\n<p><strong>New York Genome Center<\/strong><\/p>\n<p>We are starting a new collaboration with the Lappalainen lab that was made possible by a pilot grant from the Vagelos Precision Medicine Initiative at Columbia University.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:40px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 20px 20px 10px 20px;\"><div class=\"fusion-menu-anchor\" id=\"Richard Mann\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-2 fusion_builder_column_inner_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"width:25%;width:calc(25% - ( ( 2% ) * 0.25 ) );margin-right: 2%;margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"awb-image-frame awb-image-frame-2 imageframe-liftup\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-2\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"http:\/\/themannlab.org\" target=\"_blank\" aria-label=\"mann\" rel=\"noopener noreferrer\"><img decoding=\"async\" width=\"240\" height=\"270\" src=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/mann.jpg\" alt class=\"img-responsive wp-image-111\" srcset=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/mann-200x225.jpg 200w, https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/mann.jpg 240w\" sizes=\"(max-width: 800px) 100vw, 240px\" \/><\/a><\/span><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-3 fusion_builder_column_inner_3_4 3_4 fusion-three-fourth fusion-column-last\" style=\"width:75%;width:calc(75% - ( ( 2% ) * 0.75 ) );margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><h3><a href=\"http:\/\/themannlab.org\" target=\"_blank\" rel=\"noopener\">Richard Mann<\/a><\/h3>\n<p><strong>Columbia University Medical Center<\/strong><\/p>\n<p>With the Mann lab, we have pioneered the SELEX-seq approach, a combination of experimental and computational methods that allows us to perform\u00a0in vitro\u00a0profiling of protein-DNA interactions at unprecedented resolution (Slattery et al., Cell, 2011; Abe et al., Cell, 2015). Recently, we developed EpiSELEX-seq, which allows us to directly quantify the effect of cytosine methylation on protein-DNA interaction. This allowed us to discover that binding of many transcription factors, including p53 tetrameters and Hox-cofactor complexes can be modulated by DNA modification (Kribelbauer et al., Cell Report 2017). Our collaboration is funded by National Human Genome Research Institute.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:40px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 20px 20px 20px 20px;\"><div class=\"fusion-menu-anchor\" id=\"Coleen Murphy\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-4 fusion_builder_column_inner_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"width:25%;width:calc(25% - ( ( 2% ) * 0.25 ) );margin-right: 2%;margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"awb-image-frame awb-image-frame-3 imageframe-liftup\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-3\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"http:\/\/themannlab.org\" target=\"_blank\" aria-label=\"murphy\" rel=\"noopener noreferrer\"><img decoding=\"async\" width=\"240\" height=\"240\" src=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/murphy.jpg\" alt class=\"img-responsive wp-image-112\" srcset=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/murphy-200x200.jpg 200w, https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/murphy.jpg 240w\" sizes=\"(max-width: 800px) 100vw, 240px\" \/><\/a><\/span><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-5 fusion_builder_column_inner_3_4 3_4 fusion-three-fourth fusion-column-last\" style=\"width:75%;width:calc(75% - ( ( 2% ) * 0.75 ) );margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-3\"><h3><a href=\"http:\/\/www.molbio1.princeton.edu\/labs\/murphy\/\" target=\"_blank\" rel=\"noopener\">Coleen Murphy<\/a><\/h3>\n<p><strong>Princeton University<\/strong><\/p>\n<p>The Murphy lab at Princeton University studies the genetic and molecular mechanisms underlying longevity and variation in life span. Our collaboration started with our computational discovery that PQM-1 is a major functional antagonist of the well-known FOXO\/DAF-16 transcription factor and responsible for about half of the life span extension seen in long-lived mutant worms (Tepper et al., Cell, 2013). We are currently following up on these findings in a project funded by the National Institute on Aging.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:40px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 20px 20px 20px 20px;\"><div class=\"fusion-menu-anchor\" id=\"Miles Pufall\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-6 fusion_builder_column_inner_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"width:25%;width:calc(25% - ( ( 2% ) * 0.25 ) );margin-right: 2%;margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"awb-image-frame awb-image-frame-4 imageframe-liftup\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-4\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"http:\/\/themannlab.org\" target=\"_blank\" aria-label=\"pufall\" rel=\"noopener noreferrer\"><img decoding=\"async\" width=\"240\" height=\"240\" src=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/pufall.jpg\" alt class=\"img-responsive wp-image-116\" srcset=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/pufall-200x200.jpg 200w, https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/pufall.jpg 240w\" sizes=\"(max-width: 800px) 100vw, 240px\" \/><\/a><\/span><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-7 fusion_builder_column_inner_3_4 3_4 fusion-three-fourth fusion-column-last\" style=\"width:75%;width:calc(75% - ( ( 2% ) * 0.75 ) );margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\"><h3><a href=\"https:\/\/pufall.lab.uiowa.edu\/\" target=\"_blank\" rel=\"noopener\">Miles Pufall<\/a><\/h3>\n<p><strong>The University of Iowa<\/strong><\/p>\n<p>The collaboration with the Pufall lab got started at Cold Spring Harbor during the summer course on\u00a0<a href=\"https:\/\/meetings.cshl.edu\/courses.aspx?course=C-DATA&amp;year=18\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?hl=en&amp;q=https:\/\/meetings.cshl.edu\/courses.aspx?course%3DC-DATA%26year%3D18&amp;source=gmail&amp;ust=1518791311101000&amp;usg=AFQjCNFvsW0YakU3Y1qJoyK2ceDBPpzxGA\">Statistical Methods for Functional Genomics<\/a>, which our lab has been co-organizing and teaching for a decade now. We recently published a paper showing that minor groove readout underlies a difference in DNA binding specificity between two steroid hormone receptors that play important roles in cancer (Zhang et al., 2018). Ongoing work focuses in Cas9 specificity (<a href=\"https:\/\/www.biorxiv.org\/content\/early\/2017\/08\/15\/176255\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?hl=en&amp;q=https:\/\/www.biorxiv.org\/content\/early\/2017\/08\/15\/176255&amp;source=gmail&amp;ust=1518791311101000&amp;usg=AFQjCNF7a3NUkVHjbjFFgBBQejr007PqSw\">bioRxiv, 2017<\/a>).<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:40px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 20px 20px 5px 20px;\"><div class=\"fusion-menu-anchor\" id=\"Remo Rohs\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-8 fusion_builder_column_inner_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"width:25%;width:calc(25% - ( ( 2% ) * 0.25 ) );margin-right: 2%;margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"awb-image-frame awb-image-frame-5 imageframe-liftup\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-5\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"http:\/\/rohslab.cmb.usc.edu\" target=\"_blank\" aria-label=\"rohs\" rel=\"noopener noreferrer\"><img decoding=\"async\" width=\"240\" height=\"240\" src=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/rohs.jpg\" alt class=\"img-responsive wp-image-107\" srcset=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/rohs-200x200.jpg 200w, https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/rohs.jpg 240w\" sizes=\"(max-width: 800px) 100vw, 240px\" \/><\/a><\/span><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-9 fusion_builder_column_inner_3_4 3_4 fusion-three-fourth fusion-column-last\" style=\"width:75%;width:calc(75% - ( ( 2% ) * 0.75 ) );margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-5\"><h3><a href=\"http:\/\/rohslab.cmb.usc.edu\" target=\"_blank\" rel=\"noopener\">Remo Rohs<\/a><\/h3>\n<p><strong>University of Southern California<\/strong><\/p>\n<p>The Rohs lab at USC investigates the role of variation in DNA shape in protein-DNA binding specificity. Our collaboration started with the discovery of \u201clatent specificity\u201d of Hox proteins (Slattery et al., Cell, 2011) and of the striking sequence and methylation sensitivity of DNase I when cleaving naked DNA, both of which can be explained in terms of DNA shape readout. Most recently, we have created a general resource for analyzing the effect of cytosine methylation on DNA shape and Hox protein binding (Rao et al., 2018). Our collaboration is funded by National Human Genome Research Institute.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:40px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 20px 20px 20px 20px;\"><div class=\"fusion-menu-anchor\" id=\"Bas van Steensel\"><\/div><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-10 fusion_builder_column_inner_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"width:25%;width:calc(25% - ( ( 2% ) * 0.25 ) );margin-right: 2%;margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"awb-image-frame awb-image-frame-6 imageframe-liftup\"><span class=\" fusion-imageframe imageframe-dropshadow imageframe-6\" style=\"-webkit-box-shadow: 3px 3px 7px rgba(0,0,0,0.3);box-shadow: 3px 3px 7px rgba(0,0,0,0.3);\"><a class=\"fusion-no-lightbox\" href=\"http:\/\/themannlab.org\" target=\"_blank\" aria-label=\"vansteensel1\" rel=\"noopener noreferrer\"><img decoding=\"async\" width=\"240\" height=\"218\" src=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/vansteensel1.jpg\" alt class=\"img-responsive wp-image-118\" srcset=\"https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/vansteensel1-200x182.jpg 200w, https:\/\/bussemakerlab.org\/site\/wp-content\/uploads\/2018\/02\/vansteensel1.jpg 240w\" sizes=\"(max-width: 800px) 100vw, 240px\" \/><\/a><\/span><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-11 fusion_builder_column_inner_3_4 3_4 fusion-three-fourth fusion-column-last\" style=\"width:75%;width:calc(75% - ( ( 2% ) * 0.75 ) );margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-6\"><h3><a href=\"http:\/\/research.nki.nl\/vansteensellab\" target=\"_blank\" rel=\"noopener\">Bas van Steensel<\/a><\/h3>\n<p><strong>Netherlands Cancer Institute<\/strong><\/p>\n<p>Our collaboration with the Van Steensel lab goes back more than 15 years. Together, we have pioneered the role of \u201chotspots\u201d of transcription factor binding also known as \u201cHOT&#8221; regions (Moorman et al., PNAS, 2006); the partitioning of chromatin into different types or \u201ccolors\u201d (Filion et al., Cell, 2010), and most recently the use of massively parallel reporter assays in human cells (Van Arensbergen, Nature Biotechnology, 2017).<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"nf_dc_page":"","footnotes":""},"class_list":["post-60","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/pages\/60","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/comments?post=60"}],"version-history":[{"count":19,"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/pages\/60\/revisions"}],"predecessor-version":[{"id":176,"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/pages\/60\/revisions\/176"}],"wp:attachment":[{"href":"https:\/\/bussemakerlab.org\/site\/wp-json\/wp\/v2\/media?parent=60"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}